Idiopathic Inflammatory Myositis
Idiopathic inflammatory myositis
(IIM) is a systemic autoimmune disease with heterogeneous subgroups, mainly
characterized by muscle pain and muscle weakness caused by muscle inflammation.
IIM diagnoses are based on clinical, laboratory, radiological,
electrophysiological, and histopathological findings. IIM can be divided into subgroups
in tight of new myositis-specific autoantibodies (MSA), histopathological
developments, and classification criteria. These are dermatomyositis (DM),
immune-mediated necrotizing myopathy (IMNM), overlap myositis (OM), inclusion
body myositis (ICM), amyopathic dermatomyositis (ADM), polymyositis (PM), and
cancer-associated myositis. Different subgroups have different clinical,
histopathological findings, autoantibody profiles, prognosis, and treatment
responses. 30-40% of patients achieve clinical remission with treatment, but
10% have recurrent disease. Mortality is usually due to cardiac (22%),
pulmonary complications (22%), infections (15%),and malignancy (11%). IIM is
related to an increased risk of heart disease, but the prevalence remains
unclear. Approximately 70% of patients may have only subclinical symptoms. The
three main causes of cardiac mortality in IIM patients are congestive heart
failure, myocardial infarction, and arrhythmias. Evaluation of cardiac function
at the time of diagnosis and during follow-up in every patient with myositis is
important for early diagnosis and treatment, even in patients with remission.
Kitap Adı:
Cardio-rheumatology
Atıf Sayısı :
