Mistletoe is a hemiparasitic plant that can live
attached to various plants. In some cultures, it was regarded as a plant that
never touched the ground and was ascribed various meanings. It has been used in
public medicine for numerous conditions, including hypertension, diabetes,
neurological diseases and diarrhea. There are many species of mistletoe plants,
and it can be found on various types of plants and shrubs. Subcutaneous forms
of standard mistletoe extracts are available in countries like Germany, Austria
and Korea. Numerous preclinical studies have explored the potential benefits of
mistletoe extract. In the oncology, there have been randomized and controlled
studies in various types of cancer, including breast cancer, head and neck
cancer, gastrointestinal cancers, gynecological cancers, gliomas, and
pancreatic cancer. Although mistletoe extracts seem to demonstrate a survival
benefit in some studies, they have often been shown to reduce
chemotherapy-related side effects and improve quality of life. No clinically
significant drug interactions have been observed when using mistletoe extract
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