Turmeric, scientifically named Curcuma longa, is a
herbaceous plant of the ginger family (1). Curcuma longa yields flavonoids,
alkaloids, tannins, and phenolic acids, among other metabolites (2). The
bioactive ingredient curcumin, which is isolated from the rhizomes of
pulverized curcuma longa, garners interest due to its effects on secondary
metabolites (3,4). Turmeric powder has been used in traditional Indian and
Chinese medicine for hundreds of years to treat a variety of conditions, including
rheumatological disorders, sinusitis, uveitis, conjunctivitis, wound healing,
liver and biliary tract diseases, anorexia, and wound healing. (5,6) One of the leading causes of death worldwide is
cancer. It is challenging to treat cancer with single-target medications due to
the numerous cellular signaling pathway abnormalities that occur during the
disease’s development (7). Numerous studies have examined curcumin’s potential
role in cancer chemoprevention and therapeutic measures due to its combination
of pharmacological, anti-inflammatory, apoptotic, anti-proliferative,
anti-oxidant, and anti-angiogenic properties (8). Because it controls the expression
of numerous microRNAs and alters signaling pathways like Akt, Bcl-2, PTEN, p53,
Notch, and Erbb, this molecule has a high potential for therapeutic benefit, as
highlighted in numerous publications (9). Studies both in vivo and in vitro
have reported on the correlation between curcumin and various forms of cancer.
We’ll talk about how it affects stomach, colorectal, lung, and breast cancers
here.
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