Genetics Of Testicular Tumors

Yayın Yılı: 2023
Sayfa Sayısı: 215-222
Kitap Dili : Türkçe

Testicular cancer has been reported to be the most common solid malignancy in young males. The risk factors are reported to be; hypospadias, cryptorchidism, impaired spermatogenesis. The family history of testicular cancer in first degree relative may increase the risk of testicular tumors. Testicular germ cell tumors (TGCTs) are known to be the most common tumor in young white men with having a high heritability estimated to be 37–49%, and family history and cryptorchidism reported to be the strongest known risk factors, whereas no evidence regarding environmental risk factors have been defined. Also, dynamic epigenetic changes reported to occur during the male germ cell cycle. Patterns of DNA methylation and histone modifications in TGCTs are reported to be different from those in somatic cancers.

Bu kitabın bölümleri bulunmamaktadır.

Atıf Sayısı :