Geriatri Ve Primer Sklerozan Kolanjit

Yayın Yılı: 2023
Sayfa Sayısı: 81-86
Kitap Dili : Türkçe

Anahtar Kelimeler


Primary sclerosing cholangitis (PSC) is a rare, progressive, cholestatic, immune-mediated hepatobiliary disease. Although 90% of patients with PSC have inflammatory bowel disease (IBD), only 2.4-4% of patients with ulcerative colitis and 1.4% of patients with Crohn’s disease have PSC. The association between PSC and hepatobiliary malignancies and colorectal cancer is well established. Diagnostic criteria are elevated serum alkaline phosphatase levels persisting for more than 6 months, cholangiographic findings of bile duct strictures detected by magnetic resonance cholangiopancreatography (MRCP) or endoscopic retrograde cholangiopancreatography (ERCP) and exclusion of secondary causes of sclerosing cholangitis. Liver transplantation is the only proven effective treatment for patients with advanced PSC to date.

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