Primary Biliary
Cholangitis (PBC) is a generally progressive, autoinflammatory cholestatic
liver disease. It begins in the small intrahepatic bile ducts, affects the
liver tissue and progresses to cirrhosis. Early diagnosis of the disease is
possible with laboratory parameters and autoantibodies. However, missing a
diagnosis or not considering it, especially in the elderly, may cause a delay
in diagnosis. This situation also negatively affects the response to treatment.
Although it is a rare disease in people over the age of 65, it is important to
keep it in mind in diagnosis. The main treatment is UDCA (Ursodeoxycholic acid)
and it should be started immediately after diagnosis and continued for life.
UDCA improves laboratory parameters and extends life expectancy. UDCA response
should be evaluated in the sixth month or first year of treatment. In addition
to UDCA, obeticholic acid is another treatment option in unresponsive patients.
Liver transplantation should be considered in cases of jaundice, hepatocellular
carcinoma, complications of portal hypertension or persistent pruritus.
Kitap Adı:
Gastroenteroloji Ve Geriatri
Atıf Sayısı :
